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Gene Pair Information
Gene Pair: SGK1, SLC2A1
Related Sentences
# |
PMID |
Sentence |
1 |
16443776
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GLUT1 contains a consensus site ((95)Ser) for phosphorylation by SGK1.
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2 |
16443776
|
Tracer-flux studies in Xenopus oocytes and HEK-293 cells demonstrated that GLUT1 transport is enhanced by constitutively active (S422D)SGK1.
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3 |
16443776
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The effect requires the kinase catalytical activity since the inactive mutant (K127N)SGK1 failed to modulate GLUT1.
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4 |
16443776
|
GLUT1 stimulation by (S422D)SGK1 is not due to de novo protein synthesis but rather to an increase of the transporter's abundance in the plasma membrane.
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5 |
16443776
|
These observations suggest that SGK1 regulates GLUT1 and may contribute to or account for the PI3 kinase-dependent but PKB-independent stimulation of GLUT1 by insulin.
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