Ignet

Gene Pair: SIRT1, MAPK8

Related Sentences

#	PMID	Sentence
1	19996381	Here, we show that knockdown of SIRT1 in the mouse macrophage RAW264.7 cell line and in intraperitoneal macrophages broadly activates the JNK and IKK inflammatory pathways and increases LPS-stimulated TNFalpha secretion.
2	21540183	In this study, we investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation in obese mice.
3	21540183	Mouse SIRT1 is phosphorylated by JNK1 at Ser-46 (Ser-47 in human SIRT1), which is one of the four potential residues targeted by JNK1.
4	21540183	In vivo, SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1.