Ignet

Gene Pair: TFAM, PPARGC1A

Related Sentences

#	PMID	Sentence
1	10603304	The expression of both mtDNA (by mtTFA) and nDNA for oxphos and UCP (by NRFs, etc.) is coordinated by a factor called PGC-1.
2	16631115	Peroxisome proliferation-activated receptor-gamma (PPAR-gamma) coactivator-1 alpha (PGC-1alpha) increases mitochondrial transcription factor A (Tfam) resulting in mitochondrial DNA content increase.
3	16631115	The PGC-1alpha protein bearing glycine had impaired coactivator activity on Tfam promoter-mediated luciferase.
4	16631115	These results suggest that PGC-1alpha variants with Gly/Gly at 482nd amino acid may impair the Tfam transcription, a regulatory function of mitochondrial biogenesis, resulting in dysfunctional mtDNA replication.