Ignet

Gene Pair: TGFB1, AKT1

Related Sentences

#	PMID	Sentence
1	19543271	Akt kinase is activated by transforming growth factor-beta1 (TGF-beta) in diabetic kidneys, and has important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells.
2	19543271	However, the mechanisms of Akt activation by TGF-beta are not fully understood.
3	19543271	Here we show that TGF-beta activates Akt in glomerular mesangial cells by inducing the microRNAs (miRNAs) miR-216a and miR-217, both of which target PTEN (phosphatase and tensin homologue), an inhibitor of Akt activation.
4	19543271	Akt activation by these miRs led to glomerular mesangial cell survival and hypertrophy, which were similar to the effects of activation by TGF-beta.